Calendar

Research Supported by the PhRMA Foundation Funding

  • Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin. Journal of Controlled Release 122 (2007) 16 - 23. Younsoo Bae, Rita A. Buresh, Tracy P. Williamson, Tze-Haw Howard Chen, Darin Y. Furgeson. [pdf]

  • A mutation in the GABAA receptor α1 subunit linked to human epilepsy affects channel gating properties. Neuropharmacology 46 (2004) 629-637. Janet L. Fisher. [pdf]

  • Additivity in protein-DNA interactions: how good an approximation is it? Nucleic Acids Research. 2002; 30(20):4442-4451. Benos P, Bulyk ML, Stormo GD. [Link]

  • Altered Disposition of Acetaminophen in Mice With a Disruption of the mrp3 Gene. Hepatology, Vol. 42, No. 5, 2005. José E. Manautou, Dirk R. de Waart, Cindy Kunne, Noam Zelcer, Michael Goedken, Piet Borst and Ronald Oude Elferink. [pdf] Featured in Hepatology Highlights. [pdf]

  • Alternative mRNA Splicing of SMRT Creates Functional Diversity by Generating Corepressor Isoforms with Different Affinities for Different Nuclear Receptors. J Biol Chem 280:7493-503, 2005. Goodson, M. L., B. A. Jonas, and M. L. Privalsky. [Link]

  • Arsenite Delays Progression through Each Cell Cycle Phase and Induces Apoptosis following G2/M Arrest in U937 Myeloid Leukemia Cells. The Journal Of Pharmacology And Experimental Therapeutics, Vol. 313, No. 2:877-887, 2005. Geniece McCollum, Peter C. Keng, J. Christopher States, and Michael J. McCabe, Jr. [pdf]

  • Beyond Fast Track for Drug Approvals. N Engl J Med 351;5. Roberts, Thomas G., Jr., M.D. & Bruce A. Chabner, M.D. [pdf]

  • Bidirectional on/off switch for controlled targeting of proteins to subcellular compartments. Journal of Controlled Release 98 (2004 379-393. Kanwal, C., S, Mu, S.e. Kern, C.S. Lim. [pdf]

  • Ca2+ -Binding Protein-1 Facilitates and Forms a Postsynaptic Complex with Cav1.2 (L-Type) Ca2+ Channels. The Journal of Neuroscience, May 12, 2004, 24(19): 4698-4708. Hong Zhoe, Seong-Ah Kim, Elizabeth A. Kirk, Alyssa L. Tippens, Hong Sun, Francoise Haeseleer, and Amy Lee. [pdf]

  • Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks (2005). Nature Biotechnology, 23(3), 377-383. di Bernardo, D, MJ Thompson, TS Gardner, SE Chobot, EL Eastwood, AP Wojtovich, SJ Elliott, SE Schaus & JJ Collins. [Link]

  • Chemotherapy and the war on cancer. Nature Reviews, Vol 5, January 2005. 65-72. Chabner, Bruce A., M.D., & Thomas G. Roberts, Jr., M.D. [pdf]

  • Comparison of Bilayer and Monolayer Properties of Phospholipid Systems Containing Dipalmitoylphosphatidylglycerol and Dipalmitoylphosphatidylinositol. Langmuir 2001, 17, 6622-6632. Heidi Mansour, Da-Sheng Wang, Ching-Shih Chen, and George Zografi. [pdf]

  • Computational prediction of transcription-factor binding site locations. Genome Biology. 2003; 5(1):201. ML Bulyk. [Link]

  • Correlation Among Agonist Dose, Rate of Import, and Transcriptional Activity of Liganded Progesterone Receptor B Isoform in Living Cells. Pharmaceutical Research, Vol. 20, No. 10, October 2003. Li, Henan, Guang Yan, Steven E. Kern, & Carol S. Lim. [pdf]

  • Essential role of CA2+ -binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nature Neuroscience, Vol.7, 10, October 2004. Francoise Haeseleer, Yoshikazu Imanishi, Tadao Maeda, Daniel E Possin, Akiko Maeda, Amy Lee, Fred Rieke & Krzysztof Palczewski. [pdf]

  • Expression of the type 1 corticotropin-releasing factor receptor (CRF1) in the guinea-pig enteric nervous system. J Comp Neurol. 2005, 481(3): 284-298. Liu, S., Gao, X., Gao, N., Wang, X., Hu, H.-Z., Fang, X., Wang, G., Xia, Y., Wood, J.D. [pdf]

  • Identification of Structures within GABAA Receptor α Subunits That Regulate the Agonist Action of Pentobarbital. The Journal of Pharmacology and Experimental Therapeutics. 318:1094-1101, 2006. Brandon C. Drafts and Janet L. Fisher. [pdf]

  • ModuleFinder: a tool for computational discovery of cis regulatory modules. Pacific Symposium on Biocomputing. 2005; p. 519-530. Philippakis AA, He FS, Bulyk ML. [Link]

  • Nuclear Factor Kappa B is Constitutively Activated in Prostate Cancer In Vitro and is Increased in Prostatic Intra-epithelial Neoplasia and Adenocarcinoma of the Prostate. Clin Cancer Res. 2004 Aug 15; 10(16): 5501-7. Sweeney C, Shanmugam R, Li L, Bhat-Nakshatri P, Baldridge L, Zhang S, Gardner T, Kao C, Koch M, Nakshatri H, Cheng L. [Link]

  • Practical approach for using Medicare data to estimate costs for cost-effectiveness analysis. Expert Rev. Pharmacoeconomics Outcomes Res. 5(2), 153-162 (2005). Tumeh, John W, Susan G Moore, Rachel Shapiro & Christopher R Flowers. [pdf]

  • Rapid analysis of the DNA binding specificities of transcription factors with DNA microarrays. Nature Genetics. 2004 Dec; 36(12):1331-1339. Epub 2004 Nov 14. Mukherjee S, Berger MF, Jona G, Wang XS, Muzzey D, Snyder M, Young RA, Bulyk ML. [Link]

  • Reverse-engineering transcription control networks. Physics of Life Reviews 2, 65-88. Gardner, TS & J Faith. (2005) [Link]

  • Structural Determinants of the Pharmacological Properties of the GABAA Receptor α6 Subunit. The Journal of Pharmacology and Experimental Therapeutics, 309:1108-1115, 2004. Brandon C. Drafts and Janet L. Fisher. [pdf]

  • Synaptic Activation of Metabotropic Glutamate Receptors Regulates Dendritic Outputs of Thalamic Interneurons. Neuron, Vol. 41, 611-623, February 19, 2004. Govindaiah and Charles L. Cox. [pdf]

  • The α1 and α6 subunit subtypes of the mammalian GABAA receptor confer distinct channel gating kinetics. The Journal of Physiology, 561:2 (2004) pp433-448. Janet L. Fisher. [pdf]

  • The Antiangiogenic Property of Docetaxel is Synergistic with rhuMAb-VEGF or 2-Methoxyestradiol but Antagonized by Endothelial Growth Factors. Cancer Res 2001; 61: 3369-3372. Sweeney, C., Miller, K.D., Sissons, S., Nozaki, S., Douglas K. Heilman, Jianzhao Shen , Sledge G. [Link]

  • The Influence of Water Content of Triglyceride Oils on the Solubility of Steroids. Pharmaceutical Research, Vol. 22, No. 5, May 2005. Laura M. Land, Ping Li, and Paul Michael Bummer. [pdf]

  • The Phase III Trial in the Era of Targeted Therapy: Unraveling the "Go or No Go" Decision. Journal of Clinical Oncology, Vol 21, No 19 (October 1), 2003: pp 3683-3695. Roberts, Thomas G. Jr, Thomas J. Lynch Jr, & Bruce A Chabner. [pdf]

  • The Pore Helix Dipole Has a Minor Role in Inward Rectifier Channel Function. Neuron, Vol. 47, 833-843, September 15, 2005. Daniel L. Minor, Jr. [pdf]

  • The Relationship Between Water Vapor Absorption and Desorption by Phospholipids and Bilayer Phase Transitions. Journal of Pharmaceutical Sciences, September 2006 - Published online in Wiley InterScience. Heidi M. Mansour, George Zografi. [pdf]

  • Trends in the Risks and Benefits to Patients With Cancer Participating in Phase 1 Clinical Trials. JAMA, November 3, 2004 - Vol 292, No. 17 (Reprinted). Roberts, Thomas G. Jr, MD, MSocSci, Bernardo H. Goulart, MD, Lee Squitieri, Sarah C. Stallings, PhD, Elkan F. Halpern, PhD, Bruce A. Chabner, MD, G. Scott Gazelle, MD, MPH, PhD, Stan N. Finkelstein, MD, Jeffrey W. Clark, MD. [pdf]

  • Vasoactive Intestinal Peptide Selectively Depolarizes Thalamic Relay Neurons and Attenuates Intrathalamic Rhythmic Activity. J Neurophysiol 90: 1224-1234, 2003. Sang-Hun Lee and Charles L. Cox. [pdf]